講演者：鄭　誠虎 氏（ソウル大学）
日時：７月　２日（金）　午後４時３０分から
場所： 青山学院大学　理工学部（相模原キャンパス）Ｌ棟６階　Ｌ６０３室

題目： 「Dynamic heterogeneity and cooperativity in protein folding」


要旨：
Dynamic characterization of the folding process provides invaluable
insights into the mechanism of protein folding. We propose the four-point
dynamic correlation function that (i) develops a peak at the mean
folding time, (ii) probes the dynamic heterogeneity via the peak width,
and (iii) characterizes the strength of the cooperativity through the peak
height. Here the dynamic heterogeneity refers to the multiplicity of folding
pathways or the distribution of free-energy barrier heights, whereas the
cooperativity to the extent of correlated residues during the folding process.
We present dynamic Monte Carlo simulation results for the four-point dynamic
correlation function near the folding temperature, and argue that the dynamic
characteristics therefrom rationalize contrasting folding kinetics in downhill
and two-state proteins, such as the non-exponential vs. exponential relaxation.
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